Inhibitors relations in PDGF Abstracts

The effects of PDGF on PDGF-A mRNA and polypeptide levels were prevented by the protein synthesis inhibitor cycloheximide at 3.6 microM .
Source abstract: pdgf00002.html

Alpha 2-Macroglobulin ( alpha 2M ) is a multifunctional secreted glycoprotein that serves as a ubiquitous proteinase inhibitor and as a binding protein for platelet-derived growth factor ( PDGF ) BB and homologues of PDGF-BB secreted in culture by macrophages .
Source abstract: pdgf00051.html

The serine/threonine protein kinase inhibitor , H7 , blocked PDGF A and B chain mRNA induction in response to TGF-beta .
Source abstract: pdgf00086.html

The presence of a protein-synthesis inhibitor , cycloheximide , in the culture medium did not significantly influence the PDGF A-chain mRNA level in normal mesothelial and malignant mesothelioma cell lines .
Source abstract: pdgf00097.html

In this study , we demonstrate that the proteinase inhibitor and cytokine carrier alpha 2-macroglobulin ( alpha 2M ) increases rat VSMC PDGF alpha-receptor expression .
Source abstract: pdgf00111.html

Furthermore , the strain-induced stimulatory effect on DNA synthesis of fetal lung cells was blocked by tyrphostin 9 ( 1 microM ) , a PDGF receptor-associated tyrosine kinase inhibitor , but not by its inactive structural analogue tyrphostin 1 . Antisense but not sense PDGF-beta-R ON ( 10 microM ) also abrogated the strain-enhanced DNA synthesis .
Source abstract: pdgf00142.html

Vanadate , a potent phosphatase inhibitor , induced a twofold increase in thymidine incorporation .
Source abstract: pdgf00160.html

Genistein , a tyrosine kinase inhibitor , inhibited in a dose-related manner ( 2-20 microM ) the mitogenic effect induced by either PDGF or the combination of vanadate and PDGF .
Source abstract: pdgf00160.html

PDGF A-chain mRNA levels increase when quiescent HUVE cells are treated with the protein synthesis inhibitor cycloheximide ; therefore , the effect of cycloheximide on PDGF A-chain mRNA decay was also investigated .
Source abstract: pdgf00165.html

Treatment of the cells with the protein kinase C inhibitor , Ro-31-8220 , and depletion of cellular protein kinase C by pretreatment with 4 beta-phorbol 12-myristate 13-acetate resulted in loss of PLD activation by PDGF indicating a PKC-dependent mechanism .
Source abstract: pdgf00185.html

The data indicate that the t1/2 of PDGF-alpha receptor mRNA is approximately 3.3 h after incubation with the RNA II polymerase transcription inhibitor 5,6-dichloro-1 beta-D-ribofuranosylbenzimidazole ( DRB ) .
Source abstract: pdgf00189.html

Therefore , under normal physiological conditions , native alpha 2M ( non-alpha 2M-R/LRP-recognized ) is the primary form of the proteinase inhibitor functioning as a carrier of PDGF-BB and TGF-beta 1 in the blood .
Source abstract: pdgf00197.html

HBGF-1 induction of PDGF A-chain mRNA expression occurs in the presence of the protein synthesis inhibitor cycloheximide and thus does not require de novo protein synthesis .
Source abstract: pdgf00218.html

The inhibitory effect of suramin on receptor conformation was abolished by the phosphatase inhibitor , sodium orthovanadate , suggesting that receptor phosphorylation mediated the conformational change .
Source abstract: pdgf00226.html

The inhibitory effect of suramin on receptor conformation was abolished by the phosphatase inhibitor sodium orthovanadate , suggesting that receptor phosphorylation mediated the conformational change .
Source abstract: pdgf00277.html

Comparison with the immediate early response gene c-fos demonstrated that the increase in B2 receptor mRNA was similarly inhibited by the tyrosine kinase inhibitor , tyrphostin , as well as staurosporine .
Source abstract: pdgf00298.html

However , stimulation of c-fos was slightly more sensitive to genistein , while the B2 receptor mRNA was more sensitive to inhibition by the protein kinase C inhibitor , calphostin C. The increase in cell surface B2 receptors were functionally coupled to an increase in phosphoinositide-specific phospholipase C , and the effects of PDGF were selective as there was no increase in either angiotensin II- or arginine vasopressin-induced inositol phosphate formation or intracellular calcium release .
Source abstract: pdgf00298.html

The protein kinase C inhibitor , staurosporin , completely suppressed an increase in PDGF-BB binding by high glucose , and high glucose significantly activated protein kinase C. These results indicated that PDGF-beta receptor expression was enhanced by high glucose through the activation of protein kinase C. Furthermore , we observed similar effects of high glucose on both PDGF-beta receptor expression and protein kinase C activation in rat mesangial cells and human capillary endothelial cells .
Source abstract: pdgf00303.html

Incubating cells with PDGF and -isobutyl-1-methylxanthine ( IBMX , a phosphodiesterase inhibitor ) enhanced the accumulation of cAMP and PKA activity by an additional . 5-3-fold , whereas IBMX alone was essentially without effect .
Source abstract: pdgf00304.html

The PDGF-stimulated increase in cAMP was prevented by addition of the cyclooxygenase inhibitor indomethacin , consistent with release of prostaglandins stimulating cAMP .
Source abstract: pdgf00304.html

Prolonged exposure to phorbol myristate acetate ( PMA ) , which depletes protein kinase C ( PKC ) , or staurosporine , a PKC inhibitor , did not block lyso-PC-induced increases in PDGF-B or ICAM-1 mRNA .
Source abstract: pdgf00310.html

This decrease in proliferation as well as the change in morphology of the TPA-treated cells can be blocked by the protein kinase C inhibitor GF 109203X .
Source abstract: pdgf00311.html

alpha-Amanitin , an RNA polymerase II inhibitor , blocked transcription by more than 70% .
Source abstract: pdgf00315.html

Both angiotensin-converting enzyme inhibitors S and calcium channel blockers decrease postinjury intimal thickening in vivo , but their mechanisms of inhibitory action are unclear .
Source abstract: pdgf00325.html

In this study , we tested whether lisinopril , an angiotensin-converting enzyme inhibitor , or verapamil , a calcium channel blocker , would suppress the PDGF gene expression in stimulated human saphenous vein ECs .
Source abstract: pdgf00325.html

In contrast to the effect of PMA , the inactive analog phorbol had no effect on PDGF-A chain mRNA levels , while the PKC inhibitor H7 markedly reduced the PMA-induced increment in PDGF-A chain mRNA .
Source abstract: pdgf00338.html

IL-1 beta stimulates PDGF-AA synthesis also in the presence of indomethacin , a prostaglandin synthesis inhibitor .
Source abstract: pdgf00359.html

Pretreatment with either the nonspecific lipoxygenase inhibitor ( nordihydroguaiaretic acid ) or specific inhibitors of 5-lipoxygenase ( SC-41661 and ICI-230487 ) inhibited PDGF-induced mitogenesis .
Source abstract: pdgf00401.html

The PDGF-induced signal transduction cascade was studied to determine the potential mechanism of action of the lipoxygenase inhibitors S .
Source abstract: pdgf00401.html

Transforming growth factor-beta 1 ( TGF-beta 1 ) is a potent growth inhibitor for many cell types .
Source abstract: pdgf00436.html

The protein kinase C inhibitors S , H7 and staurosporine , strongly inhibited the shear-induced PDGF gene expression in HUVEC .
Source abstract: pdgf00439.html

The cyclooxygenase inhibitors S , ibuprofen and indomethacin , were slightly inhibitory .
Source abstract: pdgf00439.html

The protein kinase inhibitors S , staurosporine and K252a , block PDGF-induced ISRE binding and -5A synthetase gene expression .
Source abstract: pdgf00447.html

Treatment with forskolin ( an activator of adenylate cyclase ) , IBMX ( a phosphodiesterase inhibitor ) , PGE1 , and isoproterenol stimulated accumulation of both cAMP and c-myc RNA , but no increase in either cAMP or c-myc RNA was seen with the inactive forskolin analog , 9-dideoxyforskolin .
Source abstract: pdgf00457.html

Differential modulation of G1 cyclins and the Cdk inhibitor p27kip1 by platelet-derived growth factor and plasma factors in density-arrested fibroblasts .
Source abstract: pdgf00491.html

Density-arrested fibroblasts contain low levels of cyclins E and A , and high levels of the Cdk inhibitor p27kip1 .
Source abstract: pdgf00491.html

The chemotactic response of F5 met was inhibited by both the PI 3-kinase inhibitor wortmannin and the phospholipase C inhibitor U-71322 .
Source abstract: pdgf00492.html

Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the -phenylaminopyrimidine class .
Source abstract: pdgf00507.html

We describe a potent protein-tyrosine kinase inhibitor ( CGP 53716 ) that shows selectivity for the PDGF receptor in vitro and in the cell .
Source abstract: pdgf00507.html

Previous reports have shown that 1 ) dsRNA , a direct activator of PKR , induces the genes c-myc , c-fos , and JE ; 2 ) 2-aminopurine , a chemical inhibitor of PKR , blocks the induction of these genes by serum ; and 3 ) activated p21ras induces a cellular inhibitor of PKR .
Source abstract: pdgf00509.html

In the present study , we investigated the effects of genistein , a tyrosine kinase inhibitor , and NiCl2 , a Ca2+ influx blocker , on PDGF-induced Ca2+ transient and on expression of c-fos and c-myc mRNA .
Source abstract: pdgf00542.html

Experiments with the nucleoside transport inhibitor nitrobenzylthioinosine suggested that the transport of c3Ado into EC was required for its inhibitory activity .
Source abstract: pdgf00548.html

Inhibition of PDGF-induced c-jun and c-fos expression by a tyrosine protein kinase inhibitor .
Source abstract: pdgf00566.html

The inductions were abolished when genistein , a specific tyrosine protein kinase inhibitor , was added concomitantly with PDGF , a condition in which DNA synthesis is known to be inhibited .
Source abstract: pdgf00566.html

Transforming growth factor-beta ( TGF-beta ) acts as a growth inhibitor , yet it can stimulate proliferation ; 1-2 fg/cell of TGF-beta 1 elicits maximal proliferation of dense and sparse cultured smooth muscle cells ( SMCs ) , whereas higher amounts are less stimulatory .
Source abstract: pdgf00568.html

The TPK inhibitor genistein blocked PDGF induction of these events , including DNA synthesis , with the exception of receptor down regulation .
Source abstract: pdgf00570.html

We have investigated the regulation of p27kip1 , a cyclin-dependent kinase inhibitor , in BALB/c 3T3 cells during growth factor-stimulated transition from quiescence ( G0 ) to a proliferative ( G1 ) state .
Source abstract: pdgf00596.html

Full repression of p27kip1 synthesis required the continued presence of PDGF and failed to occur in the presence of the RNA polymerase inhibitor , 6-dichlorobenzimidazole riboside .
Source abstract: pdgf00596.html

The effects of the protein kinase C inhibitors S on proliferation could not be ascribed to cytotoxicity .
Source abstract: pdgf00617.html

None of these stimulated melanoma cell growth consistently , whereas exogenous , acid-activated TGF- beta inhibited melanoma growth at concentrations greater than 10 ng/ml , suggesting that bioactive TGF- beta may represent a physiologic growth inhibitor .
Source abstract: pdgf00680.html

In order to examine ( indirectly ) the role of PG in mediating changes in MC DNA synthesis , indomethacin ( 1.5 x 10(-5 ) mol/l ) or the thromboxane A2 synthetase inhibitor Dazmegrel ( 10(-5 ) mol/l ) was added to the medium and DNA synthesis assessed after 72 h using 3H-thymidine incorporation ( 3H-TdR ) .
Source abstract: pdgf00739.html

Tranexamic acid , a plasmin inhibitor , abrogated the stimulation of SMC migration by IL-4 .
Source abstract: pdgf00758.html

A reductase inhibitor , we evaluated the effects of lovastatin on DNA replication and the proliferation of rat mesangial and aortic smooth muscle cells , both of which were mesenchymal origin cells .
Source abstract: pdgf00762.html

A rapid increase in activity ( maximal at min ) is followed by a lower persistent level of activity which is maximal at 4-6 h . The second peak of MAP kinase activity is markedly attenuated by the protein synthesis inhibitor cycloheximide and , consequently , is paralleled by a marked de-novo synthesis of p42 and p44 MAP kinases , as measured by immunoprecipitation of [ 35S]methionine-labeled mesangial cells and by a 700% increase in total MAP kinase protein , as detected by Western-blot analysis .
Source abstract: pdgf00772.html

The tyrosine kinase inhibitor genistein dose-dependently antagonized the inhibitory effect of PDGF-BB on IL-1 beta-stimulated PLA2 secretion , thus suggesting that tyrosine phosphorylation may be required for PDGF-BB inhibition of PLA2 gene expression in mesangial cells .
Source abstract: pdgf00832.html

The addition of indomethacin , a prostaglandin H synthase inhibitor , or nordihydroguaiaretic acid , a lipoxygenase inhibitor , did not affect PDGF-stimulated thymidine uptake into DNA .
Source abstract: pdgf00854.html

Heparin is a powerful growth inhibitor for SMC .
Source abstract: pdgf00879.html

Treatment with the tyrosine phosphatase inhibitor pervanadate further increased PLC gamma 2 tyrosine phosphorylation as well as [ 3H]IP2 and [ 3H]IP3 generation .
Source abstract: pdgf00924.html

In this communication , we demonstrate that the tyrosine kinase inhibitor herbimycin-A ( HM-A ) inhibited the effects of PDGF on SMCs in proliferation , phenotypic modulation , and reorganization of F-actin .
Source abstract: pdgf00948.html

Another tyrosine kinase inhibitor genistein also inhibited reorganization of F-actin .
Source abstract: pdgf00948.html

Since both tyrosine kinase inhibitors S reduced PDGF-dependent tyrosine phosphorylation , tyrosine kinase activities may be involved not only in proliferation but also in reorganization of F-actin .
Source abstract: pdgf00948.html

The late phase of the time-dependent epidermal growth factor ( EGF)-induced biphasic activation of the p70s6k is selectively attenuated by the specific PKC inhibitor , CGP 41,251 , a staurosporine derivative .
Source abstract: pdgf00980.html

Moreover , exposure to Ro-31-8220 , a PKC inhibitor , had significantly greater effects on the response to PMA than on that to bombesin .
Source abstract: pdgf01065.html

Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor .
Source abstract: pdgf01072.html

To assess the role of MMPs in SMC proliferation and migration and intimal thickening , we measured the effect of the synthetic MMP inhibitor BB94 ( Batimastat ) on DNA synthesis and migration of SMCs in vitro as well as the formation of a neointima after balloon injury to the rat carotid artery .
Source abstract: pdgf01072.html

Growth factor-mediated induction of ScR activity in rabbit and human SMC was blocked by the tyrosine kinase inhibitor tyrphostin 47 , whereas the induction of ScR activity in rabbit but not human SMC was blocked by the protein kinase C inhibitor MDL.29,152 .
Source abstract: pdgf01084.html

Genistein , a tyrosine kinase inhibitor , inhibited PLD activation but not DGK activation , the latter was inhibited selectively by R 59022 .
Source abstract: pdgf01110.html

This effect could be augmented by the addition of ocadaic acid , a potent phosphatase inhibitor , suggesting that protein phosphorylation plays a role in this process .
Source abstract: pdgf01127.html

We have now assessed the effect of the angiotensin-converting enzyme inhibitor enalapril on the expression of the ET-1 , TNF-alpha , PDGF-B , TGF-beta , and bFGF genes in 24-week-old rat glomeruli after streptozotocin injection .
Source abstract: pdgf01130.html

In contrast , we found that AII-stimulated mitogenesis could be inhibited in a dose-dependent manner by the growth factor inhibitor drug suramin .
Source abstract: pdgf01137.html

However , the release of [ Ca2+]i from the intracellular store of the nef-expressing cells by an endomembrane Ca2+ ATPase inhibitor , thapsigargin , revealed that these cells contained normal Ca2+ stores .
Source abstract: pdgf01140.html

The effects of hypoxia and the NO synthase inhibitor on ET-1 expression are additive .
Source abstract: pdgf01162.html

The PKC inhibitor , staurosporine , antagonized mitogenesis stimulated by ATP .
Source abstract: pdgf01178.html

Although tuna AI was a weaker ACE inhibitor than captopril , the increasing effect of tuna AI on the migration and the IL-1 generation in BAECs was slightly greater than that of captopril .
Source abstract: pdgf01185.html

The natural tyrosine kinase inhibitor erbstatin and a synthetic analog ( 1302 ) were co0pared for their inhibitory activity on EGF receptor kinase , PDGF receptor kinase and a src-type kinase from bovine brain .
Source abstract: pdgf01190.html

The protein synthesis inhibitors S cycloheximide and puromycin reversed the glucocorticoid-mediated inhibition and suggested that new protein synthesis was necessary .
Source abstract: pdgf01208.html

The protein synthesis inhibitor , cycloheximide ( 10 micrograms/ml ) , also increases the level of urokinase mRNA .
Source abstract: pdgf01295.html

A selective protein kinase C inhibitor , Ro 31-8220 , abolished induction of the 95 kDa gelatinase .
Source abstract: pdgf01302.html

PDGF-induced beta-actin mRNA redistribution was inhibited by the tyrosine kinase inhibitor herbimycin , indicating that this process requires intact tyrosine kinase activity , similar to actin filament polymerization and chemotaxis .
Source abstract: pdgf01371.html

However , when conversion of T to DHT was blocked by the 5-alpha reductase inhibitor finasteride , the levels of AR mRNA were considerably down-regulated by T ( 10-500 nM ) , particularly in the contact-inhibited cells .
Source abstract: pdgf01401.html

These effects in both types of cultures were inhibited by platelet derived growth factor ( PDGF ) ( 20 ng/ml ) , a growth factor that up-regulates AR mRNA levels , and by fadrozole ( 100 nM ) , an aromatase inhibitor of the T/estrogen conversion .
Source abstract: pdgf01401.html

The ACE inhibitor did not have detectable independent effects on the A-II induced proliferation or gene expression .
Source abstract: pdgf01460.html

Moreover , a phosphodiesterase inhibitor , -isobutyl-1-methylxanthine , and a more specific cAMP phosphodiesterase inhibitor , Ro 20-1724 , augmented the inhibition of DNA synthesis in SMC concomitant with further elevation of cAMP level .
Source abstract: pdgf01464.html

To investigate whether expression of c-sis RNA is regulated in a cell cycle dependent manner , human A172 glioblastoma cells were synchronized by either centrifugal elutriation or chemical blockage with the DNA synthesis inhibitors S hydroxyurea or aphidicolin .
Source abstract: pdgf01471.html

To evaluate the role of protein kinase C-mediated pathways in the proliferation of malignant gliomas , this study examined the effect of a protein kinase C ( PKC)-activating phorbol ester ( 12-O-tetradecanoyl-13-phorbol acetate or TPA ) and a protein kinase C inhibitor ( polymyxin B ) on deoxyribonucleic acid ( DNA ) synthesis of malignant glioma cells in vitro .
Source abstract: pdgf01479.html

We have examined the effects of the tyrosine kinase inhibitor genistein on hormone dependent cell proliferation and intracellular signalling in mouse 10T1/2 fibroblasts and rat liver T51B epithelial cells .
Source abstract: pdgf01491.html

The mitogenic effects of PMA were potentiated by cycloheximide pretreatment , and they were abolished by 3-isobutyl-1-methyl xanthine ( IBMX ; a cyclic nucleotide phosphodiesterase inhibitor ) .
Source abstract: pdgf01497.html

The effects of the kinase inhibitor staurosporine on mitogenesis in NIH/3T3 fibroblasts were characterized .
Source abstract: pdgf01512.html

Trifluoperazine and W-7 , both specific CaM inhibitors S , similarly inhibited DNA synthesis stimulated by EGF , PDGF or FBS in a dose-dependent manner , whereas W-5 , a less specific CaM inhibitor , was minimally effective .
Source abstract: pdgf01519.html

In NIH3T3 cells , the serine/ threonine phosphatase inhibitor okadaic acid and the tyrosine kinase inhibitor genistein increased Shb mRNA contents , the protein kinase C activating phorbol ester 12-O-tetradecanoyl -acetate ( TPA ) decreased the Shb mRNA content , whereas the tyrosine kinase inhibitor tyrphostin 25 and the mitogen platelet-derived growth factor ( PDGF-BB ) had no effect .
Source abstract: pdgf01545.html

OBJECTIVE : The hyaluronan-binding protein TSG-6 ( tumor necrosis factor-stimulated gene 6 ) forms a stable complex with the serine protease inhibitor , inter-alpha-inhibitor , potentiates the inhibition of plasmin activity , and has antiinflammatory effects in vivo .
Source abstract: pdgf01563.html

Recipients treated with the HMG-CoA reductase inhibitor lovastatin , which inhibits isoprenoid production , showed significantly decreased allograft intimal area after weeks , when compared with untreated recipients .
Source abstract: pdgf01575.html

5 . The antiproliferative action of A02011-1 was mimicked by 8-bromo-cyclic AMP , a membrane-permeable cyclic AMP analogue and was antagonized by 2',5'-dideoxyadenosine , an adenylyl cyclase inhibitor and by Rp-cyclic AMPS , a competitive inhibitor of cyclic AMP-dependent protein kinase ( PKA ) type I and II .
Source abstract: pdgf01597.html

In order to decide if the u-PAR mRNA increase was due to message stabilization or a consequence of transcriptional activation we used the RNA polymerase II inhibitor , 6-dichloro-1-beta-D-ribofuranosyl benzimidazole ( DRB ) during the stimulation experiments .
Source abstract: pdgf01639.html

We now report evidence that the serine/threonine kinase inhibitors H7 and H8 but not HA1004 , W-7 , and ML-7 inhibit the transcriptional induction of the JE gene by serum whereas the phosphatase inhibitor , okadaic acid , increases JE expression .
Source abstract: pdgf01648.html

We have measured the effect of the lipoxygenase pathway inhibitors S nordihydroguiaretic acid ( NDGA ) , 5,6-dehydroarachidonic acid , and baicalein on bovine capillary endothelial cell ( EC ) and aortic smooth muscle cell ( SMC ) growth in the presence or the absence of growth factors .
Source abstract: pdgf01663.html

In the present study , we focus our investigation on the similarity between a redox cycling naphthoquinone and orthovanadate ( VO ) , an oxidant generator as well as a potent phosphotyrosyl phosphatase inhibitor , in growth of 3T3-L1 cells cultured in serum-free media .
Source abstract: pdgf01695.html

Herbimycin A , a specific cytoplasmic protein tyrosine kinase inhibitor , selectively inhibited the growth of src or abl transformed cells in the serum-free medium resulting in about 10-fold or fivefold lower IC50 than those in the serum-containing medium .
Source abstract: pdgf01702.html

Our results show that stimulation by serum of dense cultures of 3T3 cells rapidly induced increased synthesis of a growth inhibitor ( mIGFBP-3 ) capable of binding IGF .
Source abstract: pdgf01715.html

Effect of cilostazol , a cyclic AMP phosphodiesterase inhibitor , on the proliferation of rat aortic smooth muscle cells in culture .
Source abstract: pdgf01725.html

Cilostazol , a cyclic AMP phosphodiesterase inhibitor , has been used as an antiplatelet agent .
Source abstract: pdgf01725.html

Most interestingly , the effects of EGF and TGF-alpha can be completely reversed by the tissue inhibitor of metalloproteinases , TIMP .
Source abstract: pdgf01743.html

Herbimycin A , a specific tyrosine kinase inhibitor , both decreases thrombin-induced mitogenesis by greater than 90% and abolishes tyrosine phosphorylation of phospholipase C ( PLC)-gamma-1 .
Source abstract: pdgf01762.html

K252a , an efficient serine/threonine protein kinase inhibitor ( IC50s of to 30 nM ) , has been shown to block the neuronal differentiation of rat pheochromocytoma PC12 cells induced by nerve growth factor ( NGF ) .
Source abstract: pdgf01764.html

Phosphorylation of p175 is not induced by treatment of the cells with the phosphatases inhibitor sodium orthovanadate .
Source abstract: pdgf01765.html

The PKC inhibitors S , staurosporine , sphingosine , and -(-5-iso-quinoline-sulfonyl)-2-methylpiperazine ( H-7 ) also antagonized both proliferation and PKC activation .
Source abstract: pdgf01789.html

Another ACE inhibitor of a different chemical class , captopril , reduced neointima formation as strongly as cilazapril ( 67 and 78% , respectively ) , but the calcium antagonist verapamil was not active as an inhibitor of neointima formation , despite similar lowering of blood pressure .
Source abstract: pdgf01810.html

The transcription inhibitor , actinomycin D , and protein synthesis inhibitor , cycloheximide , inhibited the increase in GM-CSF and G-CSF production induced by IL-1 and TNF .
Source abstract: pdgf01816.html

The induction of TH by muscle extract was ( 1 ) dose dependent ; ( 2 ) paralleled by a proportional increase in the steady-state levels of TH mRNA ; ( 3 ) greatly reduced by the RNA synthesis inhibitor alpha-amanitin or the protein synthesis inhibitor cycloheximide ; and ( 4 ) unassociated with change in the survival of neurons in culture .
Source abstract: pdgf01865.html

In addition to its effects on the secretion of PA , TGF beta enhanced the production of a proteinase inhibitor by these cells .
Source abstract: pdgf01921.html

With TGF beta , which is a growth inhibitor for certain epithelial and other cell types , the loss of the normal inhibitory response in transformed cells could have the same result as the activation of a growth-stimulatory response .
Source abstract: pdgf01923.html

Thus TGF beta is primarily a growth inhibitor and not a classical growth factor .
Source abstract: pdgf01924.html

It was found that short transient exposures to the HMG CoA reductase inhibitor 25-hydroxycholesterol temporarily blocked the cell cycle traverse in the postmitotic half of G1 ( G1pm ) , whereas cells in the subsequent cell cycle phases were unaffected .
Source abstract: pdgf01932.html